This chapter delves into the intricate world of hand biomechanics, a field that constantly challenges our understanding. It focuses on gripping, forces, and rehabilitation, exploring the complex interplay between extrinsic and intrinsic muscles during different grip types. It details how neuromuscular coordination and sensory feedback mechanisms contribute to practical hand function. The biomechanical forces involved in gripping—including compression, tension, and shear forces—are analyzed in conjunction with mathematical models for estimating grip strength. Various pathologies affecting grip function are discussed, from tendon injuries and arthritis to neurological conditions such as stroke and carpal tunnel syndrome. The chapter presents evidence-based rehabilitation strategies, including specialized exercises targeting specific muscle groups, assistive technologies, and occupational therapy interventions. Emerging innovations in hand rehabilitation technology, including soft-robotic gloves, telerehabilitation platforms, and bioinspired devices, are highlighted as promising future directions. By integrating anatomical understanding with clinical applications, this chapter serves as a valuable resource for clinicians, therapists, and researchers working to improve functional outcomes in patients with hand impairments.