Carpal tunnel syndrome (CTS) stands out as the most frequently documented nerve entrapment syndrome, impacting an estimated 3–6% of adults within the population (Joshi et al., Cureus 14(7):e27053, 2022). As this condition advances, individuals often experience a range of symptoms, including both sensory disturbances, such as numbness and tingling, and motor deficits, which can significantly impair hand function and lead to debilitating challenges in their daily activities. In this chapter, we will focus on the intricate biomechanical factors that contribute to the development of CTS and explore the physiological changes that occur following surgical decompression.