The development of metro lines is a global trend, playing a crucial role in enhancing safety, accessibility, and reducing air pollution and traffic accidents. An improved urban environment contributes to the creation of sustainable communities, supporting both the physical and mental well-being of residents in areas surrounding metro stations. Encouraging people to use the metro for their daily commutes is considered a key factor in determining the success of TOD projects in urban areas, especially in contexts where communities are transitioning to metro-based transportation. This study employs the two-step clustering analysis and decision tree model to analyze the relationship between health conditions and psychoactive substance uses in a sample of 300 residents in Ho Chi Minh City, Vietnam, to explore their intention to use the metro. The findings provide valuable insights into the integration of public health considerations within the transportation sector, contributing to the development of sustainable communities. Additionally, the research lays the groundwork for proposing solutions to increase public transport usage and support vulnerable social groups.