The rapid progress of flexible and wearable electronicWearable electronics devices has gained considerable attention for developing electrochemical sensors, flexible displays, and health monitoring devices. In recent years, the development of flexible and wearable supercapacitors has received extensive consideration owing to their simplicity of construction, inexpensive, flexible integration into textiles, lightweight, long-term stability, rapid charge-discharge, higher efficiency, and ability to bridge the power-energy gap between traditional capacitors and fuel cells and batteries. The appropriate design and synthesis of new nanostructured hybrid materials for electrode fabricationElectrode fabrication on a range of flexible-based current collectors, for example, carbon-cloth, carbon fiberCarbon fibers, graphene-coated fabric, silver-nickel-coated fabric, copper-nickel-coated polyester fabric, and so on are reviewed in this context. An analysis of the most current representative methods and active materials for newly developed high-performance wearable and flexible supercapacitors is presented. Finally, the current challenges for optimizing and enhancing the efficiency of energy storage and function of flexible and wearable supercapacitors for real-time applications are addressed, as well as future research directions and perspectives.