The creation of new materials is an important task for modern scientists, for the solution of which developers use modern modeling technologies based on the processing of large amounts of information. Modern digital technologies also used in the development of biosensors. Biosensors, which integrate biological recognition elements with transducers to detect specific analytes, play a critical role in medical diagnostics, enabling early disease detection, health monitoring, and treatment management. Meanwhile metal-organic frameworks (MOFs) have gained attention due to their unique physicochemical properties, such as large surface areas, thermal stability, and tunability, making them promising candidates for enhancing biosensor performance in terms of sensitivity, selectivity, and high functionality and modification possibilities. Developments in this area can applied to dense, high-speed and energy-efficient processing and storage of electronic/optical information. Despite substantial scientific research on biosensors and their applications, a gap exists in the review of patents specifically related to MOF-based biosensors. Based on patent information, this article provides a comprehensive analysis of inventive activity in the field of MOF-based biosensors, examining patenting trends, geographical distribution, key technological developments and challenges faced by researchers on the way to innovate and use MOF-biosensors in practice.