In the future, as more and more devices get connected to the Internet, the complexity of cyberspace defense will be something that could barely be imagined with today’s sophisticated security systems. The threat that quantum computing presents to the present cryptographic standards makes it worse amplifying these challenges, hence the need to adopt a new dimension in IoT security. The quantum-resistant blockchain-based framework for IoT security that is presented in this chapter is also in line with the goal. The work focuses on incorporating lattice-based cryptography with zero-knowledge proofs, with the goal of safeguarding against both classical and post-quantum cyber threats. The proposed theoretical model is then compared to the traditional approach to present enhanced performance and flexibility. In addition, the chapter employs every effort to explain the reality of implementing such a system in actual IoT setting for the key factors entailing security, performance, and energy consumption. Such foresight enables this work to present recommendations to IoT researchers, innovators, and policymakers on how to protect the IoT in the post-quantum era adequately.