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Parkinson’s disease and Parkinson’s plus syndromes are a group of movement disorders involving the striatonigral pathway. MRI can determine the condition to a certain extent but with limited specificity, particularly in the early stages. Nuclear medicine imaging helps provide improved sensitivity and specificity particularly using 18F-DOPA PET-CT or Iodine ioflupane 123I FP-CIT (DaTscan) SPECT-CT imaging. Nevertheless, the emerging role of 99mTechnetium (99mTc)-based radiotracers such as 99mTc-TRODAT-1 SPECT-CT imaging provides a good alternative for centers that have limited access to a PET-CT scanners and non 99mTc-based radiotracers. This write-up is a didactic sharing of experience in nuclear medicine imaging of Parkinson’s disease at a Malaysian tertiary, teaching hospital.

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Nuclear Medicine Imaging in Parkinson’s Disease - Comma or No Comma? - That is the Question

  • 会议论文

  • 发表日期：

    2025年

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  • Subapriya Suppiah,
  • Nur Azra Md Zin,
  • Ahmad Danial Ahmad Shahrir,
  • Mohd Khalil Saleh,
  • Mohd Nawawi Abdullah,
  • Vengkatha Priya Seriramulu

摘要

Parkinson’s disease and Parkinson’s plus syndromes are a group of movement disorders involving the striatonigral pathway. MRI can determine the condition to a certain extent but with limited specificity, particularly in the early stages. Nuclear medicine imaging helps provide improved sensitivity and specificity particularly using 18F-DOPA PET-CT or Iodine ioflupane 123I FP-CIT (DaTscan) SPECT-CT imaging. Nevertheless, the emerging role of 99mTechnetium (99mTc)-based radiotracers such as 99mTc-TRODAT-1 SPECT-CT imaging provides a good alternative for centers that have limited access to a PET-CT scanners and non 99mTc-based radiotracers. This write-up is a didactic sharing of experience in nuclear medicine imaging of Parkinson’s disease at a Malaysian tertiary, teaching hospital.