This paper considers the problems of three-dimensional modeling and calculation of the feed drive design of a multioperational machine with auto pallet changeover. A kinematic scheme with a rigid electric motor connection with a drive ball screw transmission (BST) along each coordinate of the basic machine layout is proposed. In the integrated automated design system KOMPAS 3D, a pallet table designed during the analysis of the workpiece change procedure was formed. When modeling the design of parts made of sheet material, new effective functionalities of the KOMPAS system, such as closed and open contours for the bending operation, as well as a geometric calculator for determining the angular parameters of the pallet table were used. Three-dimensional models of BST design with a semicircular thread profile are given. When creating a screw helical surface based on the “Spiral” command, the “Characteristic point” option to specify linear and angular dimensions was used. The BST design in the APM Screw module for the case of considering non-ideal transmissions taking into account manufacturing errors of parts in the rolling element-raceway contact was performed. The energy characteristics and the durability (resource) indicator of the BST functioning when performing the milling operation on the MC3V model machining center were calculated. In the automated mode, in the APM Screw module, the contact rigidity takes into account BST parts manufacturing error calculated. This approach provides a design concept for transmission’s operability and ways to improve it.