In conditions of martial law, an important task for the country’s economy is to develop an inclusive development model that takes into account the specific characteristics of each region. The model of inclusive development of territorial units should include environmental, economic and social components and be based on the principles of smart specialization. The objective of this article is to analyze the process of substantiating the formation of an inclusive development model for territorial units based on Smart Specialization in the context of martial law and post-war reconstruction. The research methods used in the study include content analysis, the abstract-logical method, statistical observations, and economic-statistical calculations. The authors improved methodological approaches for selecting types of economic activity based on additional indices, such as the specialization index, social efficiency index, budget efficiency index, export capacity index, and others. These methodological approaches provide a comprehensive justification for regional and territorial Smart Specialization projects, taking into account regional specifics and the characteristics of various economic activities. During the testing of these methodological approaches using the example of the Zakarpattia region, it was determined that the most significant economic activities in terms of gross value added are: temporary accommodation and food service activities, including tourism; transportation, warehousing, postal, and courier activities; creative studios; real estate transactions. The obtained results can be valuable for strategic economic planning in the region, aiming to support and develop these key industries and substantiate the region’s Smart Specialization based on economic parameters.