Focused ultrasound as a treatment for epilepsy is still in its infancy. In humans, several case reports and ongoing clinical trials have demonstrated that focused ultrasound for the treatment of subcortical targets is safe, and early results have been promising. Although the efficacy of other less invasive modalities, such as DBS and LITT, has been more thoroughly established thus far than it has for focused ultrasound, the latter offers an incisionless, same-day treatment option in the epilepsy surgeon’s toolbox. Given the underutilization of surgical treatments for epilepsy, surgeons and scientists should continue to develop the use of focused ultrasound for epilepsy to help close the treatment gap.