The safety and efficacy of Gamma Knife radiosurgery have been nicely demonstrated in patients presenting with the epilepsy type most likely to be treated surgically: mesial temporal lobe epilepsy (MTLE). The demonstration of a similar efficacy and a better functional sparing in patients at risk of verbal memory decline was possible thanks to the relative homogeneity of this patient group and the well-established outcomes in case of resection. The epilepsies of cortical origin outside the mesial temporal lobe are extremely variable from patient to patient in terms of location of the epileptogenic zone (EZ), the type (or absence) of lesion, clinical presentation, and microsurgical difficulty in case of resection. For this reason, no large homogeneous series has evaluated radiosurgery in this heterogeneous patient group. The antiepileptic effect of radiosurgery at non-necrotizing doses has been well shown both in animal models and in humans, providing us with a rationale to investigate further the potential role of radiosurgery in cortical epilepsies. The delay of action and the volume restriction of the target are the main limitations of this technique. However, radiosurgery with expert neurosurgical involvement can be discussed in cortical epilepsies when an EZ limited in volume is accurately defined by the preoperative workup and a corticectomy is considered risky due to its location.