Vertical irregularities in buildings such as abrupt changes in mass, stiffness, or geometry are common in modern architecture but can adversely affect seismic performance. These irregularities increase vulnerability to dynamic loads, necessitating advanced engineering solutions. Among various vibration control strategies, Fluid Viscous Dampers (FVDs) are highly effective, dissipating seismic energy through fluid movement and significantly reducing structural responses. This study investigates the seismic performance of vertically irregular high-rise buildings equipped with FVDs, focusing on determining the optimal placement of these dampers for enhanced energy dissipation and response control. Time History Analysis (THA) is used to simulate and evaluate dynamic behavior under seismic loading in ETABs software. The research employs six models, in which five are vertically irregular with setbacks and one is of regular shape. For each model, five configurations of FVD placement are analyzed to assess the impact of damper location on the building’s seismic response. Parameters including storey displacement, inter-storey drift, time period, and base shear are examined to determine the effectiveness of various FVD configurations. The study also identifies which model behaves best under seismic loading after FVD installation. With the use of FVD, storey displacements, base shear and time period were minimized. The optimum location of FVD was found to be at critical storeys as the percentage reduction in storey displacement was higher except in one model. Corner bay placement was the second-best option.