In this review, 79 studies on sialoglycoside clusters as antiviral agents targeting influenza virus are examined. The findings are organized into three complementary analyses. In the first analysis, the structural diversity of the clusters was categorized from simple linear scaffolds to complex nanoparticles. The second analysis showed how these structures interact with different influenza strains. In the third analysis, their virus-inhibiting effectiveness was quantified. The analysis revealed that scaffold design significantly influences antiviral performance. These insights illuminate how the molecular architecture affects virus-binding strength, guiding the development of better antiviral agents against emerging influenza variants.