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With the emergence of the novel coronavirus in 2020, influenza viruses have remained out of the spotlight for some time. However, influenza viral infections have been reported in recent years, indicating that this pathogen remains a major threat. Therefore, in addition to elucidating the molecular mechanisms underlying viral proliferation, new drugs are being actively developed. One of the most effective targets for anti-influenza drugs is the endonuclease activity of the PA subunit, a component of the viral RNA-dependent polymerase, for which a wide variety of compounds have been reported to date. In this review, we introduce 100 compounds that inhibit the activity of this enzyme and the viral proliferation efficiency, showing their potential to be used as novel anti-influenza drugs.

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Pharmacophores of Influenza Virus PA Endonuclease Inhibitors

  • 章节

  • 发表日期：

    2026年

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  • Dai Hatakeyama,
  • Masaki Shoji,
  • Takashi Kuzuhara

摘要

With the emergence of the novel coronavirus in 2020, influenza viruses have remained out of the spotlight for some time. However, influenza viral infections have been reported in recent years, indicating that this pathogen remains a major threat. Therefore, in addition to elucidating the molecular mechanisms underlying viral proliferation, new drugs are being actively developed. One of the most effective targets for anti-influenza drugs is the endonuclease activity of the PA subunit, a component of the viral RNA-dependent polymerase, for which a wide variety of compounds have been reported to date. In this review, we introduce 100 compounds that inhibit the activity of this enzyme and the viral proliferation efficiency, showing their potential to be used as novel anti-influenza drugs.