The mechanical integrity of discharge silencers for screw compressors has seen increased interest in industry. Failures of internal components of these silencers has emphasized the need for high fidelity modelling of both their acoustic and mechanical behavior. In addition, new requirements in the upcoming 6th edition of API 619 state that silencers must be evaluated on their structural integrity with respect to dynamic loading. Typical operational conditions of large, dry-running screw compressors in Vapor Recovery service are ~7 bar, with molecular weight in the range 35–55 g/mole. For future application in hydrogen systems, the other extreme of the spectrum of molecular weight may be observed (MW ~2 g/mole). This results in a large range of densities and acoustic wavelengths, that require adequate absorption performance. Discharge silencers often consist of several reactive components such as damper plates and resonators to increase the transmission loss at desired frequencies. Broadband noise suppression is improved by implementing porous material inside the silencer. This material is simulated with the Delany-Bazley model. The performance of the silencer can be evaluated with commercial finite element software such as ANSYS. This paper describes a set of experiments to determine the influence of a variety of static pressures on the porous material and thus the measured transmission loss. An industry size silencer with absorbing core is used for the experiments. This allows for a proper comparison between simulations and actual acoustic behavior of a typical silencer design. The latest release of ANSYS (2024 R2) implements a new version of the Delany-Bazley model which corrects for the change in density due to pressure. This release is used for a direct comparison between simulations and experiments. Experiments on two different porous materials show that the measured transmission loss depends on static pressure. Therefore, including the correct process conditions is critical.