Healthcare 5.0 is a philosophy that has emerged in Japan among other developed nation, becoming part of the third pillar of the Society 5.0 initiative. It is now broadly explained as tailored healthcare supported by and involving patients. The full realization of Healthcare 5.0, with direct involvement of both patients and smart devices, is only possible with the technological advancements of the last two decades: IoT, cloud computing, big data, and AI. The COVID-19 pandemic created extreme pressure on healthcare organizations to reshape their service delivery. With the development of telehealth services, many patients felt much more comfortable receiving several kinds of examinations distanced thanks to wearable sensors that could serve as health indicators, among other digital solutions available. However, we are still far from a totally technological-driven, challenge-free healthcare model, because many individuals, particularly among vulnerable groups, show a lack of literacy about health or technology that is necessary to make those services work. Healthcare 5.0 advocates the idea that patients should be partners of the healthcare service, taking control of both individual and population health processes. Wearable, implantable, or even invisible smart devices should collect real-time health and health-related data that will permit dedicated health monitoring. The remote and continuous data flow will allow early intervention in cases of decompensation, as well as the ability to treat individuals with long-term diseases more effectively through sharing decision-making with the patient. Also, researchers, public health authorities, policymakers, industry, caregivers, and other stakeholders should be able to use anonymized data for promotion, prevention, and preparation actions related to population health.