Liver tumor ablation is a focused, minimally invasive treatment with curative potential for patients with tumors of limited size and number. While success rates decline when the combined tumor and safety margin exceed 3 cm, combination with transcatheter embolization and/or computer-assisted techniques—stereotactic guidance, image segmentation and fusion to ensure complete ablation—can improve outcomes for larger lesions. The most common techniques, radiofrequency or microwave ablation, produce a non-selective coagulative necrosis that may limit use near central bile ducts; however, risk may be mitigated by ablation with chemical injection, irreversible electroporation, or histotripsy. Clinical guidelines recommend local ablation for liver cancers at high risk for surgical resection, when the entire tumor burden can be treated.