In order to meet the needs of an aging population, healthcare must adapt, especially in the area of ongoing, minimally invasive monitoring. The field of medical wearables continues to develop due to materials based on perovskites. Devices such as autonomous pacemakers, conformal photoplethysmography sensors, and gesture-responsive human–machine interfaces are made possible by their remarkable characteristics, which include piezoelectricity, long carrier diffusion lengths, and adjustable bandgaps. Perovskites have opened up new applications for radiological sensing, including power-free X-ray and γ-ray detectors and wearable monitors for real-time PET/CT imaging. These materials have improved mechanical durability, physiological stability, and biocompatibility. Because perovskite-enabled technologies integrate energy harvesting, analytics, and wireless communication, they represent a significant advancement in intelligent, self-sustaining medical wearables.