This chapter thoroughly discusses the important toxicological properties of Lantana camara, a plant that is both notably invasive and has had traditional benefits. This chapter also details the negative effects that result from lantadene triterpenoids on livestock, specifically to the degree observed in regions, where serious liver damage and photosensitization cause economic impacts. Rarely will these symptoms occur in humans, but there are cases of gastrointestinal upset, and even rarer are systemic effects, most commonly related to accidental ingestion of unripe berries. The chapter emphasizes the value of detoxification strategies, including supportive care in poisoned animals and humans, as well as advanced methods including chemical methods and selective extraction methods to make Lantana biomass safe for valorization, and also realizing the value of these plants responsibly.