This chapter explores how evaluations can foster an “ecology of evidence” to address brain health challenges, using Parkinson’s disease as a case study. It argues for integrating neurological and community interventions through dynamic, context-sensitive evaluations that move beyond singular project assessments toward sustained streams of knowledge. Drawing on realist evaluation principles, the analysis identifies multiple key learning domains, including intervention effectiveness, equity impacts, mechanisms of action, contextual adaptability, and scalability considerations. The chapter critiques conventional evaluation biases that prioritize clinical interventions over community-based approaches and emphasizes the need to address asymmetries in evidence production between these domains. Challenges such as integrating heterogeneous data streams, reconciling conflicting evidence hierarchies, and capturing longitudinal trajectories of neurodegenerative conditions are discussed. The authors propose ten principles for building robust evidence ecosystems, including prioritizing patient thriving as a core metric, leveraging developmental trajectories, and designing complexity-aware monitoring systems. These principles aim to bridge gaps between short-term project evaluations and the lifelong, multidimensional needs of individuals with brain health conditions. The chapter underscores the importance of combining scientific rigor with experiential data, advocating for evaluations that inform both personalized care and population-level strategies while respecting cultural and contextual diversity.