Anthropogenic CO2 emissions from the combustion of fossil fuels and various industrial activities are a primary driver of global warmingGlobal warming and its related climate impactsClimate. To address this challenge, carbon captureCarbon capture, utilization, and storage (CCUS)Carbon capture, utilization, and storage (CCUS) technologiesDecarbonization play a vital role in global decarbonization strategies. A range of commercially available carbon capture solutions exist, each adaptable to specific CO2 recovery applications. Once captured and purified, CO2 must be compressed for efficient transport, further processing, and long-term storage. This chapter provides a comprehensive overview of key CCUSCarbon capture, utilization, and storage (CCUS) considerations, includingDecarbonization the context of global decarbonization initiatives, CO2 product requirements, available capture technologies, and the unique thermodynamic challenges associated with CO2 compressionCO compression. It also explores the mechanical design aspects, common construction materials, compressor train configurations, shaft sealing techniques, capacity control methods, and modular design strategies for the two predominant types of CO2 compressors: centrifugal and integrally geared.