Historically Black Colleges and Universities (HBCUs) are innovating teacher preparation by integrating Artificial Intelligence (AI), Extended Reality (XR), cloud computing, and the Internet of Things (IoT) into Education Preparation Programs (EPPs). This chapter explores how these technologies create immersive, culturally responsive, and ethical simulations that build pre-service teachers’ (PSTs) pedagogical skills, self-efficacy, and classroom management. Real-time data and feedback from cloud and IoT systems allow simulations to adapt to candidate actions, supporting continuous growth. Grounded in Bandura’s Self-Efficacy Theory, Vygotsky’s Sociocultural Theory, and Kolb’s Experiential Learning Theory, these XR environments offer repeated mastery experiences in realistic and diverse settings. Culturally relevant pedagogy is central, aligning with HBCU missions to support student identity and community engagement. Five critical case studies demonstrate how these technologies improve PSTs’ confidence and effectiveness, especially in diverse classrooms. The chapter also highlights HBCUs’ leadership in developing culturally grounded simulations through cross-sector partnerships, positioning them as pioneers in tech-integrated, equity-centered teacher education.