5G and Internet of Things complement each other in contributing towards the advancements of various relevant regimes like healthcare, smart cities, and industrial automation. This combination also brings cybersecurity as potential challenge due to abrupt surge in network devices and components. This chapter addresses various concerns like the significant challenges in 5G-enabled IoT systems, gauging effectiveness of existing solution and the next-generation solutions for the protection of 5G-enabled IOT in future. The study evaluates advanced solutions such as AI-based anomaly detection, privacy-preserving analytics etc. Backed by simulations and real-world case studies, the findings highlight the practical potential of these approaches to enhance IoT security and resilience. The following chapter is expected to provide the significant mentoring to the different stakeholders like young researchers, key industry personals, law administrators for creating the awareness about various steps towards designing and maintaining 5G-enabled IoT ecosystems with security as well as scalability.