Chronic ulcers represent a significant challenge in modern medicine, with profound implications for patients’ quality of life, healthcare costs, and clinical management. The complexity of ulcer healing necessitates the development of innovative therapeutic strategies to enhance tissue regeneration and accelerate wound closure. This study investigates the effects of ascorbic acid, arginine, silver sulfadiazine, and colloidal silver on ulcer healing, aiming to elucidate their role in the restoration of skin integrity. A clinical study was conducted on 106 patients, who were divided into an intervention group and a control group. Participants were monitored for up to 75 days, with systematic recording of key clinical healing markers. The findings provide critical insights into the efficacy of these agents in modulating cellular repair mechanisms and promoting faster epithelialization. The proposed therapeutic approaches leverage the synergistic properties of these compounds, which are known for their antioxidative, antimicrobial, and tissue-repairing capabilities. Given the substantial burden of chronic ulcers on healthcare systems and their detrimental impact on patient outcomes, optimizing therapeutic interventions remains a priority. The results of this study contribute to the growing body of evidence supporting alternative and complementary treatments for chronic wound management. By refining clinical protocols and integrating these bioactive agents into standardized treatment regimens, healthcare professionals may improve healing rates, reduce complications, and enhance overall patient care.