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In this chapter, we examine the current understanding of gene expression regulation by post-transcriptional RNA processing and decay pathways in Archaea, addressing critical bottlenecks and scientific advances. We highlight the RNA degrading machines and the associated RNA helicases engaged in these processes. Our focus is on how our understanding of these pathways contributes to a more comprehensive understanding of the evolutionary relationship between Archaea and Eukarya. Integrating insights from biochemical and evolutionary research has enabled us to identify Ski2-like RNA helicases as major players in RNA decay pathways in Archaea and Eukarya. In conclusion, we propose that this RNA helicase family has evolved to connect the RNA-degrading enzymes and ribosomes, in order to regulate gene expression across Eukarya and Archaea. Moreover, the presence of the ASH-Ski2 helicase in the Asgard clade, which is more closely related to Eukarya, supports the hypothesis that a common ancestor of the Ski2-like RNA helicase existed prior the emergence of the Eukarya.

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RNA Processing and Decay Pathways in Archaea: Emerging Insights on the Function and Evolution of the Archaeal Specific Ski2-Like RNA Helicases

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  • 发表日期：

    2025年

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  • Charles Cirio,
  • Maël Ansart,
  • Emmanuelle Schmitt,
  • Marie Bouvier,
  • Béatrice Clouet-d’Orval

摘要

In this chapter, we examine the current understanding of gene expression regulation by post-transcriptional RNA processing and decay pathways in Archaea, addressing critical bottlenecks and scientific advances. We highlight the RNA degrading machines and the associated RNA helicases engaged in these processes. Our focus is on how our understanding of these pathways contributes to a more comprehensive understanding of the evolutionary relationship between Archaea and Eukarya. Integrating insights from biochemical and evolutionary research has enabled us to identify Ski2-like RNA helicases as major players in RNA decay pathways in Archaea and Eukarya. In conclusion, we propose that this RNA helicase family has evolved to connect the RNA-degrading enzymes and ribosomes, in order to regulate gene expression across Eukarya and Archaea. Moreover, the presence of the ASH-Ski2 helicase in the Asgard clade, which is more closely related to Eukarya, supports the hypothesis that a common ancestor of the Ski2-like RNA helicase existed prior the emergence of the Eukarya.