Wound healing is a multifaceted biological process influenced by numerous factors, including well-regulated biochemical and cellular mechanisms, microbial infections, and oxidative stress. Nano-biomaterials have emerged as promising agents in wound care due to their unique properties, such as small size, biocompatibility, adsorption capacity, antimicrobial properties, drug loading, and potential for targeted therapeutic delivery. Many medicinal plants used in traditional wound-healing therapies around the world are promising therapeutics for the improvement of wound-healing processes, and their effectiveness is mainly attributed to the phytocomponents present in them. This efficacy can be enhanced through nano sizing or incorporation into nanostructures. The green-synthesized nano-biomaterials, derived from plant extracts and microorganism, have gained attention mainly because of their environment friendly behavior, lower toxicity, and more biocompatibility. The green-synthesized nano-biomaterials show significant promise in wound healing through their antimicrobial, anti-inflammatory, and tissue-regenerative capabilities. While green-synthesized nano-biomaterials have uncountable advantages, it has some challenges such as selection of materials, synthesis conditions, product quality control, and agglomeration of nanoparticles that can contribute to system toxicity. Despite challenges, green nanotechnology offers a sustainable and efficient approach to advancing wound care and accelerating healing.