EduRisk “Best Practices with at-risk youth in Basic Vocational Education & Training” is a competitive research project financed by the Spanish Ministry of Science and Innovation. One of its main objectives is to describe the behavioural problems of Basic VET students in comparison with sixth-form secondary students. This analysis of results is based on a representative sample of students from the Basque Country—Spain, used in a broader study, “Drugs and School X”. The sub-sample consists of a total of N = 1748 students. Comparing Basic VET with their sixth-form peers regarding substance abuse, a higher consumption of different substances is observed, not only once in a lifetime (just trying) but also on a more regular basis (within the last month or the last week). These differences remain the same with all substances except alcohol, where sixth-form students outnumber Basic VET students. These results should make us consider a more specific/indicated prevention strategy when planning a socio-educational intervention. Basic VET should be seen as a space that facilitates students’ growth and not one that could foster stigmatisation. It is imperative that Basic VET be considered as a key educational space in which to implement educational practices that promote an inclusive and respectful learning environment.