This chapter provides a comprehensive review of interactions of main metallic dental materials from the perspective of neurofocal dentistry. It defines oral galvanism, corrosion, and biotribocorrosion when different metals are used for tooth or implant-supported rehabilitation. Identifies oral and systemic effects of corrosion and release of microparticles into the oral environment. Describes the main effects of electromagnetism generated by mobile phones on oral soft tissues and performs a nervism analysis. Highlighting five concepts: [1]. Reactions of oral tissues result from the nervous system’s symphony of excitations and inhibitions. This is an attempt to adapt to fulfil basic functions [2]. Corrosion can generate locally dystrophic tissue areas surrounding the restoration or dental implant [3]. The clinical consequence of parabiosis is no painful symptoms and only perceives changes in surrounding bone tissues when there is mobility of the implant or tooth, occlusal discomfort or severe damage to the tissues [4]. A galvanic affection can become the first or second hit to an organism. Neuro focal dentists and academics have reported Systemic effects in patients after dental treatment [5]. The concept of dominance shows how restorative experiences can become a long series of irritations of various origins that contribute to modulating tone of physiological reactions and outcomes I.