As healthcare in Asia modernises rapidly with technological advancements, the ethical ramifications of this evolving landscape have grown increasingly complex. This chapter employs a narrative review approach, synthesising findings from peer-reviewed literature, policy documents, and case studies to explore the role of Clinical Ethics Committees (CECs) in addressing these challenges in the Asian healthcare context. By integrating principles of ethical stewardship, cultural relativism, and operational dynamics, it offers insights into how CECs mediate between universal ethical standards and localised practices in diverse socio-cultural and economic contexts. CECs are presented as a critical mechanism for ensuring consistent ethical standards in patient care, safeguarding healthcare ethics amidst rapid innovation and population diversity. This chapter provides an overview and practical guide for establishing CECs within the Asian healthcare context, outlining actionable steps and operational guidelines. Additionally, it examines regional case studies that demonstrate how CECs have successfully navigated complex ethical dilemmas. By focusing on Asia, the chapter offers a timely resource for healthcare institutions, policymakers, and medical professionals striving to address the ethical complexities of modern healthcare while considering regional specificities.