Across the globe, human beings seem to share experiences of loneliness and to face a broad range of possible risk factors for it. However, they live in cultural realities with very different social norms and interpretations, implying that risk factors for loneliness can vary in how commonly they occur (i.e., different prevalence), how well they can predict loneliness (i.e., different predictive strength), and which other risk factors they signal (i.e., different meaning). This chapter summarizes theorizing about cross-cultural variation in prevalence, predictive strength, and meaning of risk factors, providing multiple concrete empirical examples. For instance, if cultural norms encourage people to live independently, social isolation can be a more prevalent risk factor for loneliness than in cultures that are very family-oriented. The less normative risk factors such as living alone or being unmarried are in a culture, the more strongly people may react to them, making them stronger predictors of loneliness. The less normative living alone is in a culture, the more living alone may signal other loneliness risks, such as separation from family to earn a living, having troubled family relationships, or facing stigma for being single. Finally, this chapter also presents strategies that people employ to feel less lonely, and how they are consistent or vary across cultures. For practice, this chapter suggests that we may need to develop interventions addressing risk factors that are most common and that most strongly predict loneliness in a specific cultural context, as well as culture-specific interrelations between different risk factors.