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Platelet-to-volume ratio (PVR) calculated from readily available complete blood counts [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and polymorphonuclear neutrophil percentage (PMN%)], combined with established markers [synovial white blood cell—WBC) count] improved the accuracy in diagnosing chronic PJI in THA (sensitivity between 96% and 98%, and specificity between 98% and 100%). The diagnostic value of blood sample next-generation sequencing (NGS) was superior to that of drainage fluid NGS and bacterial culture. Most infected individuals could be identified by blood sample NGS. Furthermore, because of its high specificity, blood sample NGS can not only detect infectious bacteria but also differentiate infectious from noninfectious bacteria.

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Periprosthetic Joint Infection in Total Hip Arthroplasty: Diagnosis

  • 章节

  • 发表日期：

    2025年

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  • E. Carlos Rodríguez-Merchán,
  • Alberto D. Delgado-Martínez

摘要

Platelet-to-volume ratio (PVR) calculated from readily available complete blood counts [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and polymorphonuclear neutrophil percentage (PMN%)], combined with established markers [synovial white blood cell—WBC) count] improved the accuracy in diagnosing chronic PJI in THA (sensitivity between 96% and 98%, and specificity between 98% and 100%). The diagnostic value of blood sample next-generation sequencing (NGS) was superior to that of drainage fluid NGS and bacterial culture. Most infected individuals could be identified by blood sample NGS. Furthermore, because of its high specificity, blood sample NGS can not only detect infectious bacteria but also differentiate infectious from noninfectious bacteria.