In the context of 21st-century education, the integration of computational thinking, robotics, programming, digital literacy, and artificial intelligence (AI) into mathematics, science, and technology curriculum is essential to effectively prepare students. This paper explores these themes within the framework of Sustainable Development Goals (SDGs), emphasizing universal access and equitable quality education for all. It examines how these technologies and methodologies can enhance teaching and learning experiences, fostering critical thinking and problem-solving skills from kindergarten through higher education. Drawing on current research and educational practices, the discussion includes insights into continuous teacher training initiatives and interdisciplinary collaboration to support the implementation of these innovations in educational settings. By addressing these topics, this paper contributes to the ongoing discourse on modernizing education to meet the demands of a technology-driven society and prepares students for future challenges in mathematics, science, and technology. The integration of computational thinking and AI into the mathematics curriculum not only enhances students’ learning experiences but also equips them with essential skills for navigating an increasingly complex and interconnected world.