When secondary and tertiary productive activities displace primary ones, spatial overlap between them can lead to social conflict, economic disruption, and environmental impacts. In emergent economies such as Mexico, mutually acceptable coexistence between activities is very rare because their interests diverge, and regulatory public policy has been shaped separately for each. This is mainly due to a lack of effective methodological assessment tools to evaluate the correlative effects of interactions between productive activities and to develop articulated planning strategies. This chapter has two complementary sections. The first describes the transformations in the Sonda de Campeche region of Mexico when oil extraction replaced fishing as the principal productive activity. It explains how these two extractive activities share space in this region and how this interaction has impacted society and ecosystems. The second is a proposal for an analytical framework to evaluate regional socioecological, socioeconomic, and enviro-economic factors using interdimensional indicators linked to Sustainable Development Goals and targets. It is a broadly integrated approach that incorporates all regional actors and all relevant data to generate an assessment that can contribute to planning that respects stakeholder interests, sustains revenues, supports regional social well-being, and promotes ecological stability.