The paper presents the results of experimental studies of multilayer nanostructured wear-resistant coatings from high-entropy cathodes - targets on cutting tools made of hard alloy VK10 ОМ during turning of titanium alloys VT18U and VT41 used in the design of critical parts of modern machines and mechanisms. These structural parts in most cases are exposed to high specific loads, operate at temperatures up to +900 °C and at high temperatures in various aggressive gas environments, including those saturated with combustion products. At the preliminary stage to provide a comprehensive assessment of the functional characteristics of the developed high-entropic wear-resistant coatings, a series of test tests were carried out according to a comprehensive methodology, including the methodology and improved installation for the evaluation of tribotechnical properties, followed by a series of wear-resistance tests on a lathe and screw-cutting machine in a wide range of changes in the cutting elements. Based on the results of the conducted research, high efficiency and informativeness of the complex methodology of functional testing of operational properties of innovative high-entropy wear-resistant coatings for blade cutting of titanium alloys have been confirmed.