In today’s organizations, employee readiness in terms of their preparedness, skill sets, and capabilities is essential to meet current and future organization demands by adapting, reskilling, and upskilling to seize the opportunities that come in the way of functioning. Employee preparedness is the need of the hour in a dynamic workspace to contribute effectively and efficiently to achieve a company’s competitive advantage. The chapter discusses how artificial intelligence (AI) helps reshape employees and their preparedness in the rapidly evolving workspace. This chapter explores AI applications for employee readiness in onboarding, career progression, employee well-being, and mental health. Also, the chapter depicts the challenges of AI implementation for a company’s employee readiness and use cases. Employee readiness is no longer a static concept but a dynamic and continuous process. As workplaces evolve, organizations must prioritize initiatives that prepare their workforce for change, foster resilience, and cultivate a culture of lifelong learning. In doing so, they can ensure that their employees remain motivated, productive, and equipped to contribute to long-term organizational success.