In this chapter, self-driving cars (SDCs) are analyzed, arguably one of the most promising applications of modern technology in intelligent transportation and human mobility. This technology will likely cause individuals to worry about its possible consequences on their legal status. The importance and applicative nature of events with SDCs indicate the relevance of such a study and the need to delve into the legal ideas on criminal liability of SDCs for any accidents. In this chapter, the authors propose that legislators take action to create consistent legal standards that control the use of SDCs. It seeks to establish the legal standards governing the custody of persons blamed for accidents arising from adopting intelligent transportation systems. It stressed the urgent need to create appropriate legislative or regulatory frameworks under which SDC developers and system operators are obliged to work, coupled with the need to change traffic rules to help regulate the use of SDCs and keep pace with new technological developments.