Smoking cessation is a challenging process that involves frequent setbacks and failures. Although most smokers wish to quit, only a small percentage succeed without medical help. With support, success rates improve, and repeated quit attempts increase the likelihood of long-term cessation. Frameworks have been developed to help guide the smoking cessation process. The "5 A’s" framework, recommended by the US Public Health Service and endorsed by organizations like the WHO and the American College of Cardiology (ACC), provides a structured approach to smoking cessation. Pharmacologic treatments include FDA-approved options like varenicline, bupropion, and nicotine replacement products, which help manage cravings and withdrawal symptoms. The most effective treatments, according to the ACC, include varenicline and combination nicotine replacement therapy. Non-pharmacological treatments, such as behavioral therapies, have been shown to be more effective when combined with pharmacologic treatments. Evidence supports the use of phone-/text-based support, counseling, psychotherapy, and ongoing clinical advice. However, interventions like acupuncture, hypnotherapy, and electrostimulation have little proven efficacy.