In the realm of donation management, transparency and accountability remain significant challenges, often resulting in diminished trust from donors due to inadequate tracking of fund utilization. This paper explores the potential of blockchain technology to address these challenges by providing a decentralized, immutable ledger that transparently records all donation transactions. We investigate the use of six encryption algorithms—RSA, RC4, DES, Chacha20, Blowfish, and AES—within a blockchain framework to secure sensitive information related to donations. By analyzing the encryption and decryption performance of these algorithms, we aim to identify the most suitable encryption strategies for maintaining both security and efficiency in blockchain-based donation platforms. Additionally, this study evaluates four Ethereum Virtual Machine (EVM)-compatible platforms—BNB Chain, Fantom, Polygon, and Celo—based on their transaction fee structures, with the objective of determining the most cost-effective options for implementing blockchain technology in the non-profit sector. The findings provide a comprehensive guide for selecting appropriate blockchain solutions and encryption methods, promoting greater transparency and trust in donation management systems.