This chapter considers the higher education institutional dimension of change that transcends contexts of time and space. It is underscored here that an institutional introspection of higher education provides a systemic understanding of the change processes and offers a helpful baseline for engagement with other dimensions of higher education utility, such as teaching and learning, knowledge production, and community relevance. The chapter also furthers the historical analysis of South Africa’s socio–political context and the evolution of South African Higher Education. The chapter introduces the University of the Free State and Nelson Mandela University as grounding scenarios to support the theorisation of Higher Education institutional change within the South African context. These institutions provide contrasting yet complementary cases of institutional responses to broader social, political, and epistemological challenges, particularly in light of calls for transformation, equity, and decolonisation.