Stress cardiac magnetic resonance imaging (CMR) has emerged as a valuable tool in the assessment of patients with known or suspected coronary artery disease (CAD). It is a non-invasive modality that provides accurate information on cardiac function, myocardial ischemia, and the presence and extent of a myocardial scar with no radiation exposure. This chapter provides an overview of the indications of stress CMR, different stress pharmacological agents available and their contraindications. We also discuss the role of stress CMR in risk stratification, detection of myocardial ischemia, and viability assessment. Additionally, we list a simple flowchart that can be used for the interpretation of stress CMR.