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In addition to transducing free energy between different forms [1], a molecular machine can also transduce free energy within itself, between internally coupled components [2, 3]. \(\textrm{F}_\textrm{o}\textrm{F}_1-\) ATP synthase and transport motors like kinesin pulling diffusive cargo are two paradigmatic examples. Synthetic molecular machines are likewise often assembled from two or more components [4, 5]. To facilitate future design of synthetic molecular machines, it is critical to understand how components of a multicomponent molecular machine work both in isolation and together to transduce free energy.

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Inferring Subsystem Efficiencies in Bipartite Molecular Machines

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  • 发表日期：

    2025年

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  • Matthew Leighton

摘要

In addition to transducing free energy between different forms [1], a molecular machine can also transduce free energy within itself, between internally coupled components [2, 3]. \(\textrm{F}_\textrm{o}\textrm{F}_1-\) ATP synthase and transport motors like kinesin pulling diffusive cargo are two paradigmatic examples. Synthetic molecular machines are likewise often assembled from two or more components [4, 5]. To facilitate future design of synthetic molecular machines, it is critical to understand how components of a multicomponent molecular machine work both in isolation and together to transduce free energy.