The increasing global interest in sustainable and renewable construction materials has led to a rise in the number of mid- to high-rise timber buildings. As interest in these structures increases, understanding their behaviour under blast loads becomes crucial due to the heightened potential risk. The possibility of collapse of tall mass timber structures due to blast loads not only poses risks to occupants but can also cause significant damage to infrastructure. An overview of the key blast parameters and dynamic analysis approach used in blast design are discussed. Material characteristics of lumber, timber, cross-laminated timber, glulam and timber connections under blast loads as well as retrofitting options are reported from research findings and blast design standards. This chapter provides designers and engineers with a roadmap and design framework for blast analysis and design of a new structure or evaluation of blast vulnerability of an existing structure that might require retrofitting.