This paper explores the application of blockchain technology, smart contracts, encrypted Non-Fungible Tokens (NFTs), and the InterPlanetary File System (IPFS) in managing health records. The digitalization of health records, while beneficial, introduces significant challenges in terms of data security, privacy, and management. Our proposed framework leverages the decentralized, immutable, and transparent nature of blockchain technology to address these issues. By integrating RSA, RC4, DES, ChaCha20, Blowfish, and AES encryption algorithms with NFTs, the framework ensures that health records are secure, unique, and accessible only by authorized parties. Smart contracts automate various operations, enhancing system efficiency and reliability. We evaluated the framework’s performance on Binance Smart Chain, Polygon, Fantom, and Celo, focusing on system adaptability, operational speed, and cost efficiency. Our findings suggest that this integrated approach could significantly enhance the management and security of health records, presenting a viable solution for the healthcare sector’s digital management needs.