Human resources are not just labour for the organisation; their physical, mental, and spiritual strength represents the organisation's performance. The banking industry is considered a major player contributing to the global economy. The Indian banking sector has, in recent years, faced many challenges like mergers of banks, privatisation of banks, etc. This study aimed to understand the role of a flexible mindset between mindfulness and work-life balance among the managers of commercial banks in Kerala. This study adopted a multi-stage stratified sampling technique to select the sample from the population. A mixed-methods research approach was taken to conduct the study. The data was collected through qualitative and quantitative methods. In the first phase, 12 managers were interviewed, and based on the responses, a qualitative analysis was done. The second quantitative analysis phase was administered through primary data, constituting 200 questionnaires. The mediation effect was analysed using structural equation modelling (SEM). The result shows that a flexible mindset acts as a full mediator between mindfulness and work-life balance. The research suggests managerial implications for the Indian banking industry and directions for future research.