Callinectes sapidus (the blue crab) is a crustacean native to the western Atlantic Ocean and the Gulf of Mexico. Renowned for its ecological and economic importance, it plays a vital role in marine ecosystems as both prey and predator. We sequenced, assembled, and annotated the mitogenome of a blue crab. The assembled mitochondrial genome resulted in 16,263 base pairs of circular DNA with 30.90% GC content. Annotation predicted 13 protein-coding genes, 22 transfer RNAs, and 2 ribosomal RNA genes. The phylogenetic tree showing the mitochondrial genomes of Calinectes sapidus and 9 other species of Portunidae alone indicated that Callinectes sapidus voucher shares a close relationship with an individual from the same species, Callinectes sapidus, whose mitogenome was produced by another research group. This genome provides a valuable resource for studying blue crab evolution, population genetics, and species conservation.