Wound healing involves inflammation, proliferation, and remodeling phase, leading to scar formation. Scars can have undesirable physiological and psychological consequences, including erythema, pigmentation disorders, and emotional challenges. Autologous fat grafting (AFG) has gained popularity due to its regenerative effects on scar tissue. Adipose-derived stem cells (ADSCs) found within adipose tissue have shown significant regenerative effects on various processes associated with wound healing, particularly in dermal scars. Recent research has highlighted the proangiogenic abilities of ADSCs like those found in bone marrow-derived stem cells. Studies have demonstrated that ADSCs secrete angiogenic and antiapoptotic factors, differentiate into endothelial cells, integrate into vessels, promote neovascularization in ischemic tissues, exhibit immunomodulatory properties, secrete cytokines, and have the capacity to differentiate into multiple cell lineages. Clinical studies have reported dramatic improvement of a variety of symptoms attributed to scars after the application of ADSCs. Significant improvements in ultrastructural tissue characteristics and neovessel formation were observed along with notable clinical improvements. Histological examination following AFG reveals skin that more closely resembles non-scarred tissue. In conclusion, ADSCs have shown promising potential for scar tissue regeneration and related conditions. Further research into their properties and advantages could pave the way for innovative scar treatment strategies.