Lipofilling for facial rejuvenation is a sophisticated and effective procedure that addresses volume loss and provides patients with natural and long-lasting results. When combined with other rejuvenation techniques, such as facelifts, fillers, laser treatments, and platelet-rich plasma (PRP), it offers a comprehensive approach to facial revitalization. Case studies show its efficacy in specific regions like the periorbital and nasolabial folds, while postoperative care and management of complications contribute to successful outcomes. Lipofilling continues to demonstrate high patient satisfaction, making it a valuable option in the ever-evolving landscape of facial rejuvenation methods. This chapter presents the planning and execution of facial rejuvenation using lipofilling (and additive procedures) to develop a patient-individualized therapy concept.