Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are known to enhance tissue repair by stimulating the body’s own healing cascades through growth factors and cytokines. Lipofilling aims to restore volume in an autologous way, but graft resorption still represents a challenge, which PRP/PRF may reduce. PRP is derived from the patient’s own anticoagulated blood via centrifugation. PRP is a fluid substance that is almost free of red blood cells and rich in platelets and can be either rich or poor in leucocytes. PRF is similar to PRP but free of anticoagulants and therefore, it produces a fibrin matrix that releases growth factors over time. Depending on the preparation technique, PRF can be produced in a temporary fluid or solid state. PRP/PRF enhances fat graft viability through several factors, the most important one may be angiogenesis/improvement in blood supply. Selection of a PRP/PRF system delivering a reliable platelet concentration and enough volume is crucial, as research showed that an addition of 20–40% of PRP/PRF to the fat graft is required for optimal outcomes. Current evidence shows that PRP/PRF-assisted lipofilling provides higher fat survival rates. Beyond lipofilling, PRP/PRF can be useful for facial rejuvenation, hair restoration, wound healing, etc.