Abiotic stresses, their impact on plants, and their regulation and mitigation adopted by plants are the focus of studies from several decades. Understanding these relatable questions can provide opportunities to improve crop yield and productivity which are the key requirement in global scenarios to improve the hunger index with the growing population. Here we focus on the of plants’ sensing and regulatory mechanisms under various abiotic stresses. In this, several integrated pathways have been studied which involve Ca+2 ion signaling, phytohormones, TFs (Transcription factors), and sensory mechanisms. The regulatory mechanism altogether regulates the regulation of stress-perceptive genes to improve stress tolerance. The study can be helpful to marker-assisted breeding to grow better and more stress-resilient varieties of different crops.