This chapter discusses cognitive-behavioral group therapy along several dimensions. First, group therapy is discussed in the context of structural racism. Cognitive-behavioral group therapy with Black Americans is briefly discussed more broadly before the efficacy of cognitive-behavioral group therapy with Black Americans is explained. Yalom’s therapeutic factors and their intersections with Black Americans in cognitive-behavioral group therapy are also discussed. Racial/ethnic comfort is identified in the context of the RESPPECTUS principles. Finally, the RESPPECTUS principles and their applications to cognitive-behavioral group therapy with Black clients are delineated.